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KMID : 0370219930370060615
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Yakhak Hoeji
1993 Volume.37 No. 6 p.615 ~ p.620
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Palladium-Catalyzed Coupling between Quinolone Moieties and Heteroaryl Stannes -Synthesis of C-7 heteroaryl Quinolone Derivatives
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남상훈/Nam SH
함원훈/김기수/임태균/양재권/Ham WH/Kim KS/Lim TG/Yang JG
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Abstract
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The cross-coupling reaction of organo tin reagents with a variety of organic halides, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond. We used this method for the antibacterial agents, and synthesis of new quinolone derivatives which have carbon-carbon bond at C-7 position of general quinolone moieties. Aryl tin, quinolone moieties, and palladium catalyst were refluxed in DMF to afford new quinolone derivatives. This palladium catalyzed coupling reactions have capacity for further synthetic elaboration.
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KEYWORD
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